What's New in Targeted Therapy for Mesothelioma
Targeted therapies are drugs that block the growth and spread of cancer. Sometimes called "molecularly targeted therapies," "precision medicines," or molecularly targeted drugs," targeted therapies work by interfering with specific molecules or “molecular targets” that are involved with the progression, growth, and spread of cancer. Per the American Cancer Society, “researchers have learned more about the changes in cells that cause cancer,” so “they have developed newer drugs that target these changes.”
One of the most prominent targeted therapy drugs for cancer, specifically for rare and difficult-to-treat cancers, is Sunitinib Malate (Sutent). The drug is approved by the Food and Drug Administration (FDA) for the treatment of advanced kidney cancer, gastrointestinal stromal tumors, and advanced pancreatic neuroendocrine tumors (pNET). However, researchers have studied the therapy on many other types of cancer, including malignant pleural mesothelioma.
Other new drugs target mesothelin—a protein found in high levels in mesothelioma cells. The drug anti-mesothelin immunotoxin (SS1P) is being studied by Roche in collaboration with the National Cancer Institute (NCI), while amatuximab (MORAb-009) has received orphan drug designation for malignant pleural mesothelioma. Amatuximab studies are ongoing and are being conducted by Morphotek, also in collaboration with NCI.
Per the National Cancer Institute, “many targeted cancer therapies have been approved by the Food and Drug Administration (FDA) to treat specific types of cancer.” Others are being studied in clinical trials, and many more are in preclinical testing.
"Amatuximab (MORAb-009) Chimeric Antibody - Mesothelioma Treatment." Morphotek.com. Morphotek, Inc., 2017. Web. 28 Feb. 2017.
Kelly, Ronan J., Elad Sharon, Ira Pastan, and Raffit Hassan. "Mesothelin Targeted Agents in Clinical Trials and in Preclinical Development." Molecular Cancer Therapeutics. U.S. National Library of Medicine, Mar. 2012. Web. 28 Feb. 2017.
Nowak, Anna K., Michael J. Millward, Jenette Creaney, Roslyn J. Francis, Ian M. Dick, Arman Hasani, Agatha Van Der Schaaf, Amanda Segal, Arthur W. Musk, and Michael J. Byrne. "A Phase II Study of Intermittent Sunitinib Malate as Second-Line Therapy in Progressive Malignant Pleural Mesothelioma." Journal of Thoracic Oncology 7.9 (2012): 1449-456. Web. 28 Feb. 2017.
"Study of the Safety and Efficacy of Amatuximab in Combination With Pemetrexed and Cisplatin in Subjects With Unresectable Malignant Pleural Mesothelioma (MPM). (ARTEMIS)." ClinicalTrials.gov. U.S. National Institutes of Health (NIH), 08 Feb. 2017. Web. 28 Feb. 2017.
"Sutent." Sutent.com. Pfizer Oncology, Feb. 2017. Web. 28 Feb. 2017.
"Targeted Cancer Therapies Fact Sheet." National Cancer Institute (NCI). National Institutes of Health (NIH), 25 Apr. 2014. Web. 28 Feb. 2017.
"What's New in Malignant Mesothelioma Research and Treatment?" American Cancer Society. American Cancer Society, Inc., 2017. Web. 28 Feb. 2017.
Zhao, Xiao-Yan, Babu Subramanyam, Nenad Sarapa, Sven Golfier, and Harald Dinter. "Novel Antibody Therapeutics Targeting Mesothelin In Solid Tumors." Clinical Cancer Drugs. Bentham Science Publishers, Oct. 2016. Web. 28 Feb. 2017.