Doctors describe how mesothelioma grows and spreads with 4 stages. Patients diagnosed with stage 1 or stage 2 mesothelioma have the most treatment options. Patients with stage 3 or 4 can improve their quality of life with palliative treatments. Clinical trials are an option for patients at any stage.
The stage of a mesothelioma tumor describes how far it’s spread from where it first appeared in the protective lining of the lungs, abdomen, or heart. The spread of mesothelioma is known as metastasis. The farther mesothelioma has spread, the later doctors stage the disease.
Doctors use imaging tests and biopsies to determine your cancer stage. The results of your diagnosis help them decide which treatments fit your needs, and which will have the most positive impact on your prognosis.
Stage 1: There’s no spread to lymph nodes and the cancer is localized to one side of the body. This is the earliest stage. Stage 1 patients have the most treatment options. Learn More >
Stage 2: Mesothelioma is still localized to one side of the body but there are signs of metastasis to nearby lymph nodes. Aggressive treatment options are still an option. Learn More >
Stage 3: The first significant signs of metastasis have occurred. Mesothelioma has spread to lymph nodes and surrounding organs. Surgical options become limited. Learn More >
Stage 4: Mesothelioma has spread to the other side of the body. Treatment options for stage 4 patients primarily involves relieving symptoms. Learn More >
Pleural Mesothelioma Stages
Doctors use 4 stages to describe the spread, or metastasis, of pleural mesothelioma. Each stage details how far the tumor has spread from where it first appeared in the pleura, the protective lining of the lungs. Your doctor may also refer to the cancer stage of mesothelioma as early or advanced. Early–stage mesothelioma includes stages 1 and 2, while advanced–stage includes stages 3 and 4.
Stage 1 Pleural Mesothelioma
The growth of stage 1 pleural mesothelioma is limited to the lining of one lung. During stage 1, the tumor can also spread from the outer lining of the lung (closer to the wall of your chest) to the inner lining (closer to the lung itself).
Patients diagnosed with stage 1 mesothelioma have the most favorable prognosis compared to more advanced stages of the disease. Stage 1 tumors are more responsive to curative treatment — like surgery, chemotherapy, or radiation therapy — because the tumor is limited to the lining of one lung and easier for doctors to remove.
Stage 2 Pleural Mesothelioma
Like stage 1, most of the growth of a stage 2 tumor still occurs in the lining of one lung. At this point, however, the cancer cells may have spread to the walls of the patient's chest, diaphragm, nearby lymph nodes, or to the lung itself.
Patients diagnosed with stage 2 pleural mesothelioma have a similar prognosis to patients with stage 1. Stage 2 patients are still eligible for curative treatments that can extend life expectancy.
Stage 3 Pleural Mesothelioma
At stage 3, a tumor has spread throughout one side of the body, and has invaded at least one—or all—of the following: one lung, the diaphragm, nearby lymph nodes, and the protective lining of the heart.
The prognosis of patients diagnosed with stage 3 mesothelioma is closely linked to age and general health. Those who are healthy, and can withstand surgery, may be eligible for treatments that can extend life expectancy well past the average.
Stage 4 Pleural Mesothelioma
The growth of a stage 4 mesothelioma tumor has spread far beyond the lining of one lung. At this stage, cancer cells and secondary tumors may exist in larger sections of the chest wall, diaphragm, lining of the heart, and lymph nodes located far from the lining of the lung.
Patients diagnosed with stage 4 mesothelioma have an average life expectancy shorter than 12 months. Stage 4 patients may not be eligible for traditional curative treatment options like surgery. Patients do, however, have other options. Palliative treatments ease pain caused by the disease and have shown prognostic benefits in some cases.
Patients can also speak with their doctors about new treatments that researchers are testing in clinical trials. Some experimental therapies currently in clinical trials may become standards treatments, some of which may lead to a cure in the future.
Peritoneal and Pericardial Mesothelioma Staging
Doctors don’t usually use stages to describe the spread of peritoneal or pericardial mesothelioma. Both are rare relative to pleural mesothelioma, which accounts for 75 percent of all cases.
Doctors don’t see enough cases of peritoneal or pericardial mesothelioma to accurately describe them using stages.
Patients with peritoneal or pericardial mesothelioma are generally described as having localized or advanced mesothelioma. An experienced doctor can still assess how far the mesothelioma has spread and which treatments will work best to improve prognosis.
Symptoms caused by the spread of mesothelioma are metastatic. As a tumor grows, you’ll feel more symptoms, and they’ll happen more often. Doctors divide metastatic symptoms into two general catergories: early–stage and advanced–stage. Generally speaking, early–stage symptoms cover symptoms caused by stage 1 and stage 2 mesothelioma while advanced–stage involves stages 3 and 4.
In the early stages of metastasis, symptoms of pleural mesothelioma will feel like those caused by other illnesses of the lungs, such as pneumonia or asthma. If you’re diagnosed with early-stage mesothelioma, you may feel or experience:
- Difficulty breathing
- Persistent coughing
- Chest pain
- Weight loss
Symptoms caused by advanced–stage mesothelioma happen more often and are more specific than those caused by early-stage mesothelioma. If you have advanced–stage mesothelioma, you may feel or experience:
- Hemoptysis, or the coughing up of blood
- Dysphagia, or difficulty swallowing
- Increased fatigue
- Pleural effusions
- Night sweats
Doctors use diagnostic imaging tests to visually confirm how far mesothelioma has spread. Each type of scan provides them with visual information on the growth and spread of a tumor; information they use to determine the cancer stage of the mesothelioma.
CT Scan: A computed tomography (CT) scan generates several x-ray images doctors put together to make a single 3D image of the chest or stomach. Doctors use CT scans to determine if a tumor has spread to the chest wall or diaphragm.
MRI Scan: Doctors use a magnetic resonance imaging (MRI) scan to find out if mesothelioma has spread from the lining of the lungs, the pleura, to the chest wall, lining of the heart, or nearby organs.
Positron Emission Tomography (PET) Scan: A PET scan is the best method to determine if mesothelioma has spread to other parts of the body. Doctors can even use it to find out if a tumor has spread to lymph nodes that are far from where the mesothelioma first appeared.
Staging Systems for Mesothelioma
Doctors use three staging-systems to describe the spread of mesothelioma. These systems weren’t specifically made for the disease, and are more often used for more common lung cancers. Nevertheless, they help doctors determine how far a tumor has spread, and how possible certain treatment options are. Each system focuses on a different aspect of metastasis, but they all divide it into 4 stages.
The American Joint Committee on Cancer (AJCC) staging system emphasizes three main factors regarding the advancement and spread of pleural mesothelioma.
- T: Refers to the growth of the primary tumor.
- N: Refers to the extent the tumor has spread to nearby lymph nodes.
- M: Refers to the tumor’s spread to other organs.
The TNM system assigns numbers to each factor to describe metastasis in more detail.
After they categorize a tumor according to each individual group —T, N, and M— doctors assign it an overall stage grouping ranging from 1 to 4. They assign the stage grouping by combining the tumor’s T, N, and M values. A lower stage grouping number means that the tumor hasn’t spread far.
Doctors use the Brigham system to describe how the spread of a tumor affects their ability to surgically remove it. The Brigham system divides pleural mesothelioma into four stages:
- Stage 1: The tumor has not spread to the lymph nodes and can be removed via surgery.
- Stage 2: The tumor is mostly confined to the lining of the lung, but has spread to nearby lymph nodes. It is still possible to remove via surgery.
- Stage 3: The tumor has spread to nearby organs and body structures, such as the pericardium, chest wall, peritoneum, and diaphragm. Surgery is no longer an option.
- Stage 4: The tumor has spread to areas and organs far outside where the tumor first appeared. Surgery is no longer an option.
The oldest and most common staging method, doctors use the Butchart system to describe the location of the main tumor, rather than how large it is or how far it has spread.
- Stage 1: The tumor is in the lining of one lung, and may have spread to the lining of the heart or diaphragm. In the Butchart system, this is the stage where doctors can most effectively remove the tumor.
- Stage 2: The tumor has spread to the chest wall, and may have grown into the inner part of the lung’s lining. At this stage, it’s also possible that mesothelioma cells are present in the esophagus, heart, and lymph nodes surrounding the chest.
- Stage 3: The tumor has spread from the lining of the lung to the diaphragm or lining of the abdomen. Mesothelioma cells may have spread into lymph nodes far from the main tumor. At this stage, curative surgery is no longer a good option. Doctors may use palliative treatment may as the main form of treatment.
- Stage 4: Cancer cells have spread through the bloodstream to areas far from the main tumor. Palliative treatments are now the only available course of treatment.
Why Cancer Stage is Important
Doctors use the cancer stage of mesothelioma to determine which treatment options are available, and how effective those options will be.
If you’ve been diagnosed with early–stage mesothelioma, you’re most likely eligible for traditional treatments—surgery, chemotherapy, radiation therapy—that can extend your life expectancy. If you’ve been diagnosed with advanced–stage mesothelioma, traditional treatments may not be an option, but you can participate in clinical trials where researchers are testing newer treatments like immunotherapy.
As a patient diagnosed with mesothelioma, it’s important to know that you’re getting the best, most effective treatment possible. The key to effective treatment is a correct diagnosis; factors like the cancer stage, cell type, and location of the mesothelioma all play an important role in this respect. If you haven’t already, make sure you get a second opinion from an experienced doctor. Our Patient Help Team can review your diagnosis, connect you with an experienced specialist, and can even help you get financial aid to pay for treatment. Let us help—for free.